Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury
نویسندگان
چکیده
منابع مشابه
Curcumin attenuates myocardial ischemia–reperfusion injury
Background Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery...
متن کاملReperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia.
BACKGROUND AND PURPOSE Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and peroxynitrite in reperfusion-induced injury. However, depending on their cellular origin and interactions between them, these molecules may exert protective or deleterious action...
متن کاملMechanism of Mitochondrial Connexin43′s Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury
We observed mitochondrial connexin43 (mtCx43) expression under cerebral ischemia-reperfusion (I/R) injury, analyzed its regulation, and explored its protective mechanisms. Wistar rats were divided into groups based on injections received before middle cerebral artery occlusion (MCAO). Cerebral infarction volume was detected by 2,3,5-triphenyltetrazolim chloride staining, and cell apoptosis was ...
متن کاملExogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury
Background and Aims. Human embryonic stem cell- (hESC-) derived cardiomyocytes are one of the useful screening platforms of potential cardiocytoprotective molecules. However, little is known about the behavior of these cardiomyocytes in simulated ischemia/reperfusion conditions. In this study, we have tested the cytoprotective effect of an NO donor and the brain type natriuretic peptide (BNP) i...
متن کاملPlasma exosomes protect the myocardium from ischemia-reperfusion injury.
BACKGROUND Exosomes are nanometer-sized vesicles released from cells into the blood, where they can transmit signals throughout the body. Shown to act on the heart, exosomes' composition and the signaling pathways they activate have not been explored. We hypothesized that endogenous plasma exosomes can communicate signals to the heart and provide protection against ischemia and reperfusion inju...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2016
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2016.09.002